List of publications in peer reviewed journals and book chapters.

•  Pavez Loriè, E., Cools, M., Borgers, M., Wouters, L., Shroot, B., Hagforsen, E., Törmä, H., Vahlquist, A. (2009). Topical treatment with CYP26 inhibitor talarozole (R115866) dose dependently alters the expression of retinoidregulated genes in normal human epidermis. Br J Dermatol 160, 26–36.

•  Donders, G., Ausma, J., Wouters, L., Cauwenbergh, G., Borgers, M., Janssens, D. (2008). The efficacy of a single oral dose of 200 mg pramiconazole in vulvovaginal yeast infections: an exploratory phase IIa trial. Acta Dermatologica-Veneorologica 88, 462-466.

•  Decroix, J., Ausma, J., Cauwenbergh, G., Borgers, M., Wouters, L. (2008). The efficacy of oral treatment with pramiconazole in tinea pedis and tinea cruris/corporis: two exploratory phase IIa trials. British Journal of Dermatology 158, 836-873.

•  Bijnens, L., Wouters, L.,Verbeeck, R., Goehlmann, H., Lewi, P., (2009). Spectral map analysis of microarray data. In Walczak B., Ferre R.T., Brown S. (Eds.) Comprehensive Chemometrics. Elsevier, Amsterdam, The Netherlands

•  Piérard, G., Ausma, J., Henry, F., Vroome, V., Wouters, L., Borgers, M., Cauwenbergh, G., Piérard-Franchimont C. (2007). A pilot study on seborrheic dermatitis using pramiconazole as a potent oral anti-malassezia Agent. Dermatology 214 , 162-169.

•  Van Sanden, S., Wouters, L., Burzykowski, T., Molenberghs, G., Van Remoortere, M., Meert, T., Bijnens, L. (2006). A modeling approach to the analysis of nerve regenerative experiments. Journal of Biopharmaceutical Statistics , 16 , 843–859.

•  Piérard-Franchimont, C., Ausma, J., Wouters, L., Vroome, V., Vandeplassche, L., Borgers, M., Cauwenbergh, G., Piérard, G. (2006). Activity of the triazole antifungal R126638 as assessed by corneofungimetry . Skin Pharmacol Physiol . 19 , 50-56.

•  Vandenbroeck, P., Wouters, L., Molenberghs, G., Van Gestel, S., Bijnens, L. (2005). Teaching statistical thinking to life scientists – a case-based approach. Journal of Biopharmaceutical Statistics, 16, 61-75.

•  Wouters, L., Göhlmann, H.W., Bijnens, L., Kass, S.U., Molenberghs, G., Lewi, P.J. (2005). Rejoinder to use of principal component analysis and the GE -Biplot for the graphical exploration of gene expression data . Biometrics 61 , 632-634.

•  Straetemans, R., O’Brien, T., Wouters, L., Van Dun, J., Janicot, M., Bijnens, L.,Burzykowski, T., Aerts, M. (2005). Design an analysis of drug combination experiments. Biometrical Journal 47 , 299-308.

•  Bijnens L., Lewi P. , Goehlmann H. , Molenberghs G., Wouters L. (2004). Spectral map-analysis: a method to analyze gene expression data . – Proceedings of the American Statistical Association, Biopharmaceutical Section 553-559, American Statistical Association , . Alexandria , VA

•  Wouters, L., Göhlmann, H.W., Bijnens, L, Kass, S.U., Molenberghs, G., Lewi, P.J. (2003). Graphical exploration of gene expresion data: a comparative study of three multivariate methods. Biometrics 59, 1133-1141.

•  Engels, M.F.M., Wouters, L., Verbeeck, R., Vanhoof, G. (2002). Outlier mining in high-throughput screening experiments . Journal of Biomolecular Screening  7, 341-351.

•  Ausma, J., Litjens, N., Lenders, M-H., Duimel, H., Mast, F., Wouters, L., Ramaekers, F., Allessie, M., and Borgers, M. (2001). Time course of atrial fibrillation-induced cellular structural remodeling in atria of the goat . Journal of Molecular and Cellular Cardiology 33, 2083-94.

•  Wouters, L., Liu, G.S., Flameng, W., Thijssen, V., Thoné, F., Borgers, M., (2000). Structural remodeling of atrial myocardium in patients with cardiac valve disease and atrial fibrillation. during chronic atrial fibrillation secondary to cardiac valve disease in man. Experimental and Clinical Cardiology 5 , 158–163

•  Engelborghs, K., Haseldonckx, K., Van Reempts, J., van Rossem, K., Wouters, L., Borgers, M., Verlooy, J. (2000). Impaired autoregulation of cerebral blood flow in an experimental model of traumatic brain injury. Journal of Neurotrauma 17 ,667-677

•  Abs, R., Smets, G., Vauquelin, G., Verhelst, J., Mahler, C., Verlooy, J., Stevenaert, A., Wouters, L., Borgers, M., Beckers, A. (1997). 125I-Tyr0-hCRH labelling characteristics of corticotropin-releasing hormone receptors: differences between normal and adenomatous corticotrophs. Neurochemistry International  30, 291-297

•  Ausma, J., Wijffels, M., Thoné, F. , Wouters, L., Allessie, M., Borgers, M. (1997). Structural changes of atrial myocardium due to sustained atrial fibrillation in the goat. Circulation  96, 3157-3163

•  Haseldonckx, M., Van Reempts, J., Van De Ven, M., Wouters, L., Borgers, M. (1997) Protection with lubeluzole against delayed ischemic brain damage in rats. A quantitative histopathologic study. Stroke 28 , 428-432

•  Schoofs, A., Odds, F.C., Colebunders, R., Ieven, M., Wouters, L., Goossens, H. (1997). Isolation of Candida species on media with and without added fluconazole reveals high variability in relative growth susceptibility phenotypes. Antimicrobial Agents & Chemotherapy 41 , 1625-1635.

•  van Rossem, K., Vermarien, H., Faithfull , N.S. , Wouters, L., Decuyper, K. (1997). Effects of perflubron emulsion and 100% oxygen breathing on local tissue PO2 in brain cortex of unanaesthetized rabbits. Advances in Experimental Medicine & Biology 411 , 403-409.

•  Geerts, H., Nuydens, R., De Jong, M., Cornelissen, F., Nuyens, R., Wouters, L. (1996). Sabeluzole stabilizes the neuronal cytoskeleton. Neurobiology of Aging 17, 573-581.

•  Van Ginckel, R., Janssens, B., Callens, M., Goeminne, N., Wouters, L., De Coster, R. (1996). Effects of combined and sequential treatment with tamoxifen and the aromatase inhibitor vorozole on 7,12-dimethylbenz(a) anthracene-induced mammary carcinoma in the rat. Cancer Chemotherapy & Pharmacology 38 , 21-28

•  Dijkman, G.A., Van Moorselaar, R.J., Van Ginckel, R., Van Stratum, P., Wouters, L., Debruyne, F.M. Schalken, J.A., De Coster, R. (1994). Antitumoral effects of liarozole in androgen-dependent and independent R3327-Dunning prostate adenocarcinomas. Journal of Urology 151 , 217-222.

•  Borgers, M., De Nollin, S., Thoné, F. , Wouters, L., Van Vaeck, L., Flameng, W. (1993). Distribution of calcium in a subset of chronic hibernating myocardium in man. Histochemical Journal 25 , 312-318.

•  Borgers, M., Thoné, F., Wouters, L., Ausma, J., Shivalkar, B., Flameng, W. (1993). Structural correlates of regional myocardial dysfunction in patients with critical coronary-artery stenosis – chronic hibernation. Cardiovascular Pathology 2 , 237-245.

•  Cornelissen, F., Wouters, L., Ver Donck, L., Verellen, G., Geerts, H. (1993). Automatic quantification of the effect of cardioprotective drugs in isolated myocytes. Bioimaging  1 , 197-206.

•  Dikova, M., Van Reempts, J., Wouters, L., Clincke, G., Borgers, M. (1993). Learning performance at different time periods after hypoxia in infant rats. Acta Neurobiologiae Experimentalis  53 , 467-471.

•  Vandeplassche, G., Hermans, C., Van Dael, L., Wouters, L., De Clerck, F. (1993). Interplay between platelet-derived 5-hydroxytryptamine and arachidonic acid metabolites limits the thrombolytic efficacy of streptokinase against canine platelet-rich coronary thrombosis. Journal of Cardiovascular Pharmacology 21 , 56-69.

•  Van Ginckel, R., Distelmans, W., De Brabander, M., Callens, M., Janssens B., Jagers, E., Wouters, L., De Coster, R., Janssen ,P.A. (1992). Levamisole plus 5-fluorouracil inhibits the growth of human colorectal xenografts in nude mice. European Journal of Cancer  28A(6-7) , 1137-1139.

•  Vandeplassche, G.M. Hermans, C.F. de Chaffoy de Courcelles, D.R., D’Aubioul, J.A., Wouters, L.J., De Clerck, F.F. (1992). Comparative effects of R 80122, enoximone, and milrinone on left ventricular phosphodiesterase isoenzymes in vitro and on contractility of normal and stunned myocardium in vivo in dogs. Journal of Cardiovascular Pharmacology 19 , 714-722.

•  Weber, C., Beetens, J.R., Tegtmeier, F., Van Rooy, P., Vercammen, E., Wouters, L., De Clerck, F., (1992). Ridogrel inhibits systemic and renal formation of thromboxane A2 and antagonizes platelet thromboxane A2/prostaglandin endoperoxide receptors upon chronic administration to man. Thrombosis & Haemostasis 68 , 214-220.

•  Distelmans, W., Van Ginckel, R., Van herck, W., Willebrords, R., Wouters, L., De Brabander, M., Mesens, J. (1991). Erbulozole (P.I.N.N.) (R 55 104) encapsulated into cyclodextrins: has it a combined antitumoral and radioprotective potential ? Anticancer Research 11 , 253-256.

•  Jansen, T., Borgers, M., Van De Ven, M.A., Xhonneux, B., Wouters, L., Van Gerven, F., Van Cutsem, J. (1991). The effects of saperconazole on the morphology of Candida albicans, Pityrosporum ovale and Trichophyton rubrum in vitro. Journal of Medical & Veterinary Mycology 29 , 293-303

•  Nevelsteen, A. , Wouters, L., Suy, R. (1991). Aortofemoral dacron reconstruction for aorto-iliac occlusive disease: a 25-year survey. European Journal of Vascular Surgery 5 , 179-186.

•  Nevelsteen, A., Wouters, L., Suy, R. (1991). Long-term patency of the aortofemoral Dacron graft. A graft limb related study over a 25-years period. Journal of Cardiovascular Surgery 32 , 174-180 .

•  Van De Water, A., D’Aubioul, J., Van Gerven, W., Wouters, L., Reneman, R.S., Xhonneux, R. (1991). Astemizole: effects on the cardiovascular system of the dog. Japanese Pharmacology and Therapeutics (Yakuri to Chiryo) 19(5) , 109-122.

•  Van deplassche, G. Hermans, C., Wouters, L., Borgers, M. (1991). Effects of R 56,865, a preventer of cellular calcium overload, on left ventricular diastolic properties during pacing-induced ischemia in dogs. Journal of Cardiovascular Pharmacology 17, 621-626.

•  Van deplassche, G., Hermans, C., Van de Water, A. , Xhonneux, R., Wouters, L., Van Ammel, K., De Clerck, F. (1991). Differential effects of thromboxane A2 synthase inhibition, singly or combined with thromboxane A2/prostaglandin endoperoxide receptor antagonism, on occlusive thrombosis elicited by endothelial cell injury or by deep vascular damage in canine coronary arteries. Circulation Research 69, 313-324.

•  Vandeplassche, G., Hermans, C., Van Haecke, J., Wouters, L., Borgers, M. Flameng, W. (1991). Evaluation of factors influencing myocardial infarct size in unconscious dogs. Cardiovascular Research 25, 844-854 , 1991

•  Vandeplassche, G., Lu, H.R., Wouters, L., Flameng, W., Borgers, M. (1991). Normothermic ischemic cardiac arrest in the isolated working rabbit heart: effects of dl-nebivolol and atenolol. Basic Research in Cardiology 86, 21-31.

•  Ver Donck, L., Wouters, L., Olbrich, H.G., Mutschler, E. (1991). Effect of nebivolol on survival of cardiomyopathic hamsters with congestive heart failure. Drug Investigation 3 (Suppl 1), 82-85.

•  Ver Donck, L., Wouters, L., Olbrich, H.G., Mutschler, E., Borgers, M. (1991). Nebivolol increases survival in cardiomyopathic hamsters with congestive heart failure. Journal of Cardiovascular Pharmacology. 18,1-3.

•  Verheyen, A., Lauwers, F., Vlaminckx, E., Wouters, L., De Clerck, F. (1991). Oversensitivity to serotonin of the collateralized vascular bed in rat hindquarters – mechanisms of increased vasoconstriction. European Journal of Pharmacology 194, 209-216

•  Andries, K., Dewindt, B., Snoeks, J., Wouters, L., Moereels, H., Lewi, P.J., Janssen, P.A.J. (1990). Two groups of rhinoviruses revealed by a panel of antiviral compounds present sequence divergence and differential pathogenicity. Journal of Virology 64, 1117-1123.

•  De Clerck, F., Loots, W., Somers, Y., Beetens, J., Wouters, L., Wynants, J., Janssen, P.A. (1990). 5-Hydroxytryptamine and arachidonic acid metabolites modulate extensive platelet activation induced by collagen in cats in vivo. British Journal of Pharmacology 99, 631-636.

•  Lu, H.R. Vandeplassche, G., Wouters, L., Flameng, W., Borgers, M. (1990). Effects of beta-adrenoceptor antagonists on cardiac function in ischemic-reperfused myocardium of the isolated working rabbit heart. European Journal of Pharmacology 184, 65-74

•  Van Ginckel, R., De Coster, R., Wouters, W., Vanherck, W., van der Veer, R., Goeminne, N., Jagers, E., Van Cauteren, H., Wouters, L., Distelmans, W. (1990). Antitumoral effects of R 75251 on the growth of transplantable R3327 prostatic adenocarcinoma in rats. Prostate 16, 313-323.

•  Xhonneux, R., Wouters, L., Reneman, R.S., Janssen, P.A. (1990). The l-enantiomer of nebivolol potentiates the blood pressure lowering effect of the d-enantiomer. European Journal of Pharmacology 181, 261-265

•  Distelmans, W., Van Ginckel, R., Vanherck, W., Willebrords, R., De Brabander, M., Wouters, L., Heeres, J. (1989). Influence of the synthetic microtubule inhibitor erbulozole (P.I.N.N.) (R 55 104), a new tubulozole congener, and gamma irradiation on murine tumors in vivo. European Journal of Cancer & Clinical Oncology 25 , 1499-1504.

•  Distelmans, W., Van Ginckel, R., Vanherck, W., Willebrords, R., De Brabander, M., Wouters, L. Van den Winkel, P., De Backer, G. (1989). Interaction between the microtubule inhibitor tubulozole and gamma-irradiation in murine tumors in vivo. International Journal of Radiation Oncology, Biology, Physics 16 , 177-182.

•  Lu, H.R., Vandeplassche, G., Wouters, L., Borgers, M. (1989). Beta-blockade in the ischemic reperfused working rabbit heart: dissociation of beta-adrenergic blocking and protective effects. Archives Internationales de Pharmacodynamie et de Therapie 301 , 165-181.

•  Liu, G- S., Borgers, M., Xhonneux, R., Van Overloop, P., Thoné, F., Wouters, L., Leijssen, L., Janssen, P. (1988). Protective effects of lidoflazine and mioflazine in ischemic myocardium (in Chinese). Chinese Journal of Cardiology 16, 100-102.

•  Verheyen, A., Vlaminckx, E., Lauwers, F., Borgers, M., Wouters, L. (1987). Radioactive colloidal gold as a tool to quantify extravasation of macromolecules in the rat cremaster muscle. International Journal of Microcirculation: Clinical & Experimental 5, 321-333.

•  Liu, G.S., Borgers, M., Xhonneux, R., Van Overloop, P., Thoné, F., Wouters, L., Leijssen, L. (1986). Evaluation of protective effects of lidoflazine and mioflazine in cardiac ischemia. Drug Development Research 8, 407-416.

•  Nevelsteen, A., D’Hallewin, M.A., Deleersnijder, J., Wouters, L., Suy, R. (1986). The human umbilical vein graft in below-knee femoropopliteal and femorotibial surgery: an eight year experience. Annals of Vascular Surgery 1, 328-334.

•  Nevelsteen, A., D’Hallewin, M.A., Deleersnijder, J., Wouters, L., Suy, R. (1986). Pontages femoro-poplites bas et femoro-jambiers utilisant la veine ombilicale humaine: une experience de huit annees. Annales de Chirurgie Vasculaire 1, 328-334.

•  Sergeant, P., Wouters, L., Dekeyser, L., Flameng, W., Suy, R. (1986). Is the outcome of coronary artery bypass graft surgery predictable in patients with severe ventricular function impairment? Journal of Cardiovascular Surgery 27, 618-621.

•  Van Reempts, J., Haseldonckx, M., Van Deuren, B., Wouters, L., Borgers, M. (1986). Structural damage of the ischemic brain: involvement of calcium and effects of postischemic treatment with calcium entry blockers. Drug Development Research 8, 387-395.

•  Vandeplassche, G., Wouters, L., Hermans, C., Xhonneux, R., Borgers, M., Flameng, W. (1986). An efficient method to evaluate protective drugs against regional ischemia of the heart. Drug Development Research 8, 417-424.

•  De Clerck, F., Loots, W., Somers, Y., Van Gorp, L., Verheyen, A., Wouters, L. (1985). Thromboxane A2-induced vascular endothelial cell damage and respiratory smooth muscle cell contraction: inhibition by flunarizine, a Ca2+-overload blocker. Archives Internationales de Pharmacodynamie et de Therapie 274, 4-23.

•  De Coster, R., Beerens, D., Haelterman, C., Wouters, L. (1985). Effects of etomidate on cortisol biosynthesis in isolated guinea-pig adrenal cells: comparison with metyrapone. Journal of Endocrinological Investigation 8, 199-202.

•  Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1985). Cardiovascular effects of ketanserin in closed-chest anesthetized dogs. Archives Internationales de Pharmacodynamie et de Therapie 275, 267-278.

•  Flameng, W., Wouters, L., Sergeant, P. , Lewi, P., Borgers, M., Thoné, F., Suy, R. (1984). Multivariate analysis of angiographic, histologic, and electrocardiographic data in patients with coronary heart disease. Circulation 70 , 7-17.

•  Flameng, W., Xhonneux, R., Van Belle, H., Borgers, M., Van De Water, A., Wouters, L., Wijnants, J., Thoné, F., Van Daele P., Janssen P.A. (1984). Cardioprotective effects of mioflazine during 1 h normothermic global ischaemia in the canine heart. Cardiovascular Research 18, 528-537.

•  Kubo K., Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S., (1984). Cardiac and haemodynamic effects of intravenous administrations of flunarizine in closed-chest anaesthetized mongrel dogs. Arzneimittel-Forschung 34, 434-439.

•  Verheyen, A., Vlaminckx, E., Lauwers, F., Van Den Broeck, C., Wouters, L. (1984). Serotonin-induced blood flow changes in the rat hindlegs after unilateral ligation of the femoral artery. Inhibition by the S2 receptor antagonist ketanserin. Archives Internationales de Pharmacodynamie et de Therapie 270, 280-298.

•  De Clerck, F., Van Gorp, L., Xhonneux, B., Somers, Y., Wouters, L. (1982). Enhanced platelet turnover and prostaglandin production in spontaneously hypertensive rats. Thrombosis Research 27, 243-249.

•  De Castro J., Van De Water A., Wouters L., Xhonneux R., Reneman R., Kay B. (1979). Comparative study of cardiovascular, neurological and metabolic side effects of 8 narcotics in dogs. Pethidine, piritramide, morphine, phenoperidine, fentanyl, R 39 209, sufentanil, R 34 995. I. Comparative study on the acute toxicity and hemodynamic effects of the narcotics in high and massive doses in curarised and mechanically ventilated dog. Acta Anaesthesiologica Belgica 30, 5-54.

•  De Castro J., Van De Water A., Wouters L., Xhonneux R., Reneman R., Kay B. (1979). Comparative study of cardiovascular, neurological and metabolic side effects of 8 narcotics in dogs. Pethidine, piritramide, morphine, phenoperidine, fentanyl, R 39 209, sufentanil, R 34 995. II. Comparative study on the epileptoid activity of the narcotics used in high and massive doses in curarised and mechanically ventilated dogs. Acta Anaesthesiologica Belgica 30, 55-69.

•  De Castro J., Van De Water A., Wouters L., Xhonneux R., Reneman R., Kay B. (1979). Comparative study of cardiovascular, neurological and metabolic side effects of 8 narcotics in dogs. Pethidine, piritramide, morphine, phenoperidine, fentanyl, R 39 209, sufentanil, R 34 995. III. Comparative study of the acute metabolic toxicity of the narcotics used in high and massive doses in curarised and mechanically ventilated dogs. Acta Anaesthesiologica Belgica. 30, 71-90.

•  Wouters, L. (1979). An APL function for computing distribution-free confidence limits on the median of a population. Behavior Research Method & Instrumentation 11(3), 401.

•  Wellens, D., Wouters, L., Reneman, R.S. (1977). Aspects comparatifs de la distribution du flux sanguin dans la circulation cerebrale chez le rat, le chat et le chien. Journal de Physiologie 73, A12-A13.

•  Wellens, D., Wouters, L., Stijnen, L., Reneman, R.S. (1977). Anatomical and pharmacological characteristics of the cerebral circulation in dogs, cats and rats: contribution of the radioactive microsphere method. Bibliotheca Anatomica 15 Pt 1 , 82-86.

•  Parmentier, P., Snoeckx, L., Van De Water, A., Wouters, L. (1976). Massive doses of sulfentanil after severe asphyxia in dogs: cardiovascular and hemodynamic effects. Effects on asphyxia tolerance. Anesthesie et Reanimation Pratique 6, 81-85.

•  Wellens, D., Wouters, L., Nijkamp, F.P., De Jong, W. (1976). Distribution of the blood flow supplied by the vertebral artery in rats: anatomical, functional and pharmacological aspects. Experientia 32 , 85-87.

•  Wellens, D., De Wilde, A., Van Bogaert, A., Van Bogaert, P.P., Wouters, L., Reneman, R.S., Janssen, P.A.J. (1975). Unusual mechanism of hypotensive activity exerted by erytrho-1-(1-[2-(1,4-benzodioxan-2-yl)-2-OH-ET-a1-4-piperidyl)-2-benzimidazolinone (R 28935). Archives Internationales de Pharmacodynamie et de Therapie 215 , 91-103.

•  Wellens, D., Snoeckx, L., De Reese, R., Kruger, R., Van De Water, A., Wouters, L., Reneman, R.S. (1975). Antihypertensive activity of erytrho-1-(1-[2-(1,4-benzodioxan-2-yl)-2-OH-ET-a1-4-piperidyl)-2-benzimidazolinone (R 28935). Archives Internationales de Pharmacodynamie et Therapie 215, 119-132.

•  Wellens, D., van Bogaert, A., De Wilde, A., Wouters,L., Van Bogaert, P.P., Reneman,R.S. (1975). The effects of hypothalamic and reflexogenic hypertension on renal and femoral circulation. Archives Internationales de Physiologie et de Biochimie 83, 144-148.

•  Wellens, D.L., Wouters, L.J., De Reese, R.J., Beirnaert, P., Reneman, R.S. (1975). The cerebral blood distribution in dogs and cats. An anatomical and functional study. Brain Research 86, 429-438.

•  Wellens, D., Wouters, L., Beirnaert, P., Den Hartog, M., Reneman R.S. (1974). Invloed van noradrenaline en angiotensine op de bloeddruk en op de hersencirkulatie bij de hond, na toediening langes de arteria vertebralis Acta Clinica Belgica 29, 283-288.